That means there were only 150 particles per liter, so overall, there were now fewer particles in the plasma than in the adjacent cells. She was OVER hydrated, so the original 300 particles per liter in her plasma were now at 300 particles per 2 liters, since the excess water increased her blood volume. She developed a headache, went home, and died. When would that ever happen in real life? A contestant on a radio game show drank a lot of water for a week, and was not allowed to go to the bathroom much. What happens to the cells? They will lyse (rupture). Water will move from the plasma to the adjacent cells. Why? Because particles suck! The cells will draw the water to it. What will move, in order to dilute the cells? Water. Water always moves across the compartments because cell membranes always allow water to pass.ĭifferent compositions (different amounts of individual particles) Different volumes, Same osmolalities (total number of particles) 0.3 Osmolal = 300 mOsmolal (actually closer to 280mOsmolal) Plasma Interstitial Intracellularĩ If the plasma is diluted to 260 mOsm, and the cells next to a blood vessel are still at 300 mOsm, the cells now have more particles. If one compartment has more particles than another one next to it, and if those particles cannot reach equal numbers on their own because the cell membrane blocks their passage, water will try to dilute the compartment with the higher number of particles until they are at the same number of particles per liter. It could also be described as having “an osmolarity of 300”.ħ That means that there are 300 million particles (or 300 milliosmoles, abbreviated 300 mOsm) of things in each compartment. It does not matter about size and composition…if you can count every particle in that compartment, in all the compartments you should get the same number of particles: 300 million particles per liter, expressed as “300 million osmoles” or “300 mili-osmoles”. What is dissolved in the fluid is different. Body fluid compartments have different sizes and volumes, and different compositions. Lumen of stomach Intracellular Fluid (30-40% Body Wt) Extracellular Fluid Interstitial fluid (the water immediately outside cells, between and around cells) (16%) Plasma fluid (the water inside blood vessels, but not in blood cells) (4-5%) Transcellular fluid (the water enclosed in chambers lined by epithelial membranes) (1-3%) These are stomach epithelial cells ?Ħ If you manipulate one body fluid compartment, it has an effect on another compartment. Most medical solutions are calculated in units that don’t require a periodic table of elements, but if someone miscalculates a solution, and you inject it, and the patient crashes, you are just as liable, and you will be sued.Ĥ Water Water makes up 45-75% of our body weightħ0 kg man X 0.60 = 42 kg = 42 L How much of your own weight is water? 2.2lb/1kg Divide this into two compartments Intracellular water Extracellular waterĥ Compartments ? Intracellular Fluid (30-40% Body Wt) Examples of tonicity and osmolalityģ Why do you need to understand body fluid compartments and osmolarity calculations? Many of you will be applying IV care for patients, and sometimes doctors make mistakes, so you need to be able to catch these errors. Examples of osmotic pressure differences in body fluid compartments VII. Hydrostatic pressure- movement across capillaries V. Osmosis-movement across cell membranes due to unequal particles B. Review of Simple diffusion of solutes IV. Types of transport across the membrane for solutes-Protein transporters C. How do we have different composition/ movement of solutes A. Water compartments of the body A.Intracellularī. Presentation on theme: "Body Fluid Compartments"- Presentation transcript:Ģ Lecture outline I.
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